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Classical Pathway (Triggered by antigen fixing antibody (IgM, IgG) binds…

- - - - C4a
      - C4b
        
        C4b+C2b
      - Cleaves C2
        
        C2a
        
        C2b
- - - - MBL protease
        
        C4
        
        C4a
        
        C4b
        
        C4bC2a
        
        C2
        
        C2a
        
        C2b
- - - - C3b + Factor B
        
        Factor D converts Factor B to Bb and Ba
        
        C3 + Bb
        
        C3 Convertase
        
        C3
        
        C3b
        
        C5 convertase
        
        1 more item...
        
        C3b
        
        C3a
        
        Inflammation
        
        Factor H is a negative regulator of C3b
        
        Factor I acts as a complement regulator