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Hepatitis D (Patho (Disease (Acute (co-primary infection: occurs with…
Hepatitis D
Patho
Virus
Deltaviridae family
sole RNA virus of the genus
incomplete virus (requires the assistance of HBV-> replicate)
Disease
cause acute or chronic hepatitis
concomitant infection-> with HBV
HBsAg
Acute
co-primary infection: occurs with acute hepatitis B
superinfection : chronic hepatitis B infection
Effect
delta agent :arrow_up: severity of HBV infection
mild-> serious, fulminating hepatitis
acute hepatitis in asymptomatic carriers
increase the tendency for progression to chronic hepatitis and cirrhosis
Routes of transmission
similar~ Hep B
high risk for HBV carrier eg: injecting drug users.
HDV superinfection
treatment
vaccination
Reasons
linked to hepatitis B->prevention of hepatitis B first
Diagnosis
serum: detection of antibody to HDV(anti-HDV) & HDV RNA