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Nitazoxanide (Adverse effects (Allergic reactions (Itching/swelling, Rash)…
Nitazoxanide
Adverse effects
Diarrhea
Abdominal pain
Severe dizziness
Headache
Allergic reactions
Itching/swelling
Rash
Vomiting
Anaemia
Anorexia
Diaphoresis 发汗
Eye and urine discolouration
Hypertension
tachycardia 心动过速
Precautions
Renal impairment
Allergy
Contains inactive ingredients
Pregnancy
Hepatic impairment
Lactation
Passes into breast milk
Children <1yr
Diabetes
Contains sugar
Pharmacokinetics
Distribution
Protein-binding >99%
Metabolism
Rapidly hydrolysed to tizoxanide
Undergoes conjugation by glucuronidation
Absorption
GI tract (oral)
Extent absorption enhanced with food
Peak plasma conc. after 1-4 hrs
Excretion
Faeces (2/3 of oral dose)
Urine (remaining dose)
Dose (taken with food)
Adult
500mg every 12hr for 3 days
Child
1-3 yr
100mg every 12hr
4-11 yr
200mg every 12hr
3 days
≥ 12 yr
500mg every 12hr
Overdose
Passing out
Trouble breathing
Indication
Symptoms
Stomach cramps
Watery diarrhea
Giardia Lamblia
(Giardiasis)
Cryptosporidium parvum
(Cryptosporidiosis)
Sources
Contaminated water
Swimming pools
Contaminated food
Storage
Suspension
15-30°C
Shake well before use
Tablets
Room temp
MOA
Antiprotozoal agent
Active metabolite (tizoxanide)
Interfere with pyruvate which is essential to anaerobic metabolism in susceptible organisms
Nitazoxanide
Drug interaction
Possibly interact with highly protein-bound drugs: warfarin
Brand name
Alinia