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MPN & MDS (MyeloDysplastic Syndrome (MDS) Maturation defect
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MPN & MDS (
MyeloDysplastic Syndrome (MDS)
- Maturation defect
- Cytopenia :black_circle:
- Progression
- Simultaneous proliferation :factory: & apoptosis :explode:(haematopoietic cells)
- Ineffective haematopoiesis
- BM failure :skull_and_crossbones:
- Leukaemia risk
,
MyeloProliferative Neoplasms (MPN) :end:
- :arrow_double_up:Terminally differentiated myeloid production
,
BM exam :skull_and_crossbones:
- Both check cell morphology
- BM aspirate :potable_water:
- Cell morphology
- Complete listing of marrow cellular elements
- Flow cytometry :wavy_dash:
- Trephine biopsy :red_flag:
- Vasculature
- BM architecture
- Fibrosis
- Represents ALL cells
- IHC :flashlight:
- Cytogenetics
,
Myeloid Neoplasms
- Primarily invovles BM :skull_and_crossbones:
- Sometimes secondry haematopoetic organs :red_circle:
)