Impact of genomics on the medical industry, specifically gene editing
CRISPR immune system in bacteria
can takes parts of the virus DNA and inserts it into CRISPR sequence
Clustered regularly interspaced short palindromic repeats
CRISPR-assosciated genes
Ethical implications: gene therapy
ostracising communities?
gene editing human embryos
religious responses
1987 Yoshizumi Ishino near iap gene
same 29 bases, 32 spacers with unique seq.
2002 Ruud Jansen noticed near CRISPR there was CAS restrictive enzymes
Duodena discovered CRISPR
Discovery made by Koonin
change guide RNA
uses
transgenic animals
xenotransplantation
sarcomas
Targets multiple genes simultaneously
Novartis; use in cancer treatments
Editas Medicine
Kamel Khalili removed HIV from genome of animals 50% success rate