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Chronic Leukemia (Chronic Lymphocytic Leukaemia Mature B-cell neoplasm…
Chronic Leukemia (
Chronic Lymphocytic Leukaemia
- Mature B-cell neoplasm (clonal proliferation) :older_woman::skin-tone-3:
- Monoclonal B-cell population (single light chain :chains:, k or gamma)
- Co-express:
- B-cell lineage markers (CD 19, 20, 23)
- T-lineage (CD 5)
- Overlaps SLL:check:
- CLL = bone marrow :skull_and_crossbones: preipheral blood, extramedullary tissues
- SLL = lymph nodes
,
Chronic Myeloid Leukaemia
- Clonal, pluripotent stem cells in bone marrow
- t(9;22)(q34;q11)
- Has BCR-ABL1 (fusion gene) found in all CML but NOT specific :mag_right:
- 20% of adult leukaemia
- Chronic/insedious onset phase > accelerated phase (therapy resistant) > blast phase > leukaemia
- Male predominance
,
Monoclonal disorders of bone marrow stem cells)