A Coggle Diagram about Statins (Usually given at night to take advantage of fasting state., Adverse- rhabdo (associated with vitamin D?), high LFTs, don't give to kids or pregnant women, fatigue, Inhibit HMG CoA reductase, upregulates LDLR, Main effect- lower LDL. Also mildly lowers TG and raises HDL, Other effects- inhibits smooth muscle proliferation and thrombus formation and Broken down by CYP- don't give with inhibitors), Bile acid sequestrants, Fibric acid derivatives, Niacin (Best drug for raising HDL, prevents FFA mobilization, less VLDL from liver and Adverse- flushing from high prostaglandins. Can premedicate with NSAIDS. Can cause hyperglycemia), Ezetimibe (PNC1L1 inhibitor- brings cholesterol into the gut.) and Omega-3 fatty acids- marine ones are better.